TRAF2 (C-term) Peptide
产品名称: TRAF2 (C-term) Peptide
英文名称: TRAF2 (C-term) Peptide
产品编号: P2848
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human TRAF2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Unique signaling properties of CTAR1 in LMP1-mediated transformation.
Mainou BA, Everly DN Jr, Raab-Traub N.J Virol. 2007 Sep;81(18):9680-92. Epub 2007 Jul 11.
- 2.
- TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C.Mol Immunol. 2008 Jan;45(1):76-86. Epub 2007 Jun 27.
- 3.
- Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Morrison BH, Bauer JA, Lupica JA, Tang Z, Schmidt H, DiDonato JA, Lindner DJ.J Biol Chem. 2007 May 25;282(21):15349-56. Epub 2007 Mar 22.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of TRAF2 (arrow) using rabbit TRAF2 polyclonal antibody (Cat # PAB3506). 293 cell lysates (2 ug/lane) either nontransfected (c) or transiently transfected with the TRAF2 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with TRAF2 polyclonal antibody (Cat # PAB3506) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 7186
- Protein Accession#:
- NP_663770;Q12933
- Gene Name:
- TRAF2
- Gene Alias:
- MGC:45012,TRAP,TRAP3
- Gene Description:
- TNF receptor-associated factor 2
- Omim ID:
- 601895
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022625,OTTHUMP00000064745,tumor necrosis factor type 2 receptor associated protein 3
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